:root{color-scheme:light;--bg:#F7F4EE;--surface:#fff;--surface-soft:#f8fafc;--text:#1e293b;--muted:#64748b;--line:#e4e4e7;--primary:#0d9488;--primary-hover:#0f766e;--primary-soft:#f0fdfa;--success:#047857;--success-soft:#ecfdf5;--warning:#b45309;--warning-soft:#fffbeb;--danger:#b91c1c;--danger-soft:#fef2f2;--shadow:0 1px 2px rgba(0,0,0,.05);--radius:14px}
*{box-sizing:border-box}html{scroll-behavior:smooth;overflow-x:hidden}body{margin:0;min-height:100vh;font-family:ui-sans-serif,system-ui,sans-serif,"Apple Color Emoji","Segoe UI Emoji";background:var(--bg);color:var(--text);line-height:1.5}button,input,select,textarea{font:inherit;font-size:.875rem}button{cursor:pointer}.container{width:min(1280px,100%);margin:0 auto;padding:0 16px}.site-header{border-bottom:1px solid rgba(226,232,240,.8);background:rgba(255,255,255,.7);backdrop-filter:blur(12px);position:sticky;top:0;z-index:10;padding:16px 0}.header-inner{display:flex;align-items:center;gap:16px}.header-brand{display:flex;align-items:baseline;flex-shrink:0;line-height:1}.brand-bold{font-family:ui-serif,Georgia,serif;font-size:1.25rem;font-weight:600;color:#0f172a;letter-spacing:-.025em}.brand-light{font-size:1.25rem;font-weight:300;color:#94a3b8;margin-left:.375rem}.header-divider{width:1px;height:36px;background:rgba(203,213,225,.8)}.header-info{min-width:0}h1{margin:0;font-size:1.125rem;line-height:1.25;font-weight:600}h2{margin:0;font-size:1rem;line-height:1.25;font-weight:600}h3{margin:0;font-size:.9rem;font-weight:600}p{margin:0}.subtitle{margin-top:2px;color:var(--muted);font-size:.875rem;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}.main-grid{display:grid;gap:24px;margin-top:24px;padding-bottom:44px}.card{background:var(--surface);border:1px solid var(--line);border-radius:var(--radius);box-shadow:var(--shadow);padding:24px;overflow:hidden}.section-heading{display:flex;align-items:center;justify-content:space-between;gap:16px;margin-bottom:24px}.form-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:16px}.field{display:grid;gap:6px;min-width:0}.field>span:first-child{font-size:.875rem;font-weight:500}input,select,textarea{width:100%;min-height:36px;border:1px solid var(--line);border-radius:8px;background:var(--surface);color:var(--text);padding:4px 12px;outline:none;transition:.2s}input:focus,select:focus,textarea:focus{border-color:var(--primary);box-shadow:0 0 0 3px rgba(13,148,136,.15)}.input-with-unit{position:relative}.input-with-unit input{padding-right:54px}.input-with-unit>span{position:absolute;right:12px;top:50%;transform:translateY(-50%);color:var(--muted);font-size:.8rem}.mode-description{margin:0 0 14px;color:var(--muted);font-size:.875rem}.formula-note{margin-top:14px;padding:12px 14px;border-radius:8px;background:var(--primary-soft);color:#115e59;font-size:.8rem}.button-row{display:flex;align-items:center;gap:8px;flex-wrap:wrap}.button{min-height:32px;border-radius:8px;padding:5px 12px;border:1px solid transparent;font-size:.875rem;font-weight:500;white-space:nowrap}.button-primary{background:var(--primary);color:#fff}.button-primary:hover{background:var(--primary-hover)}.button-ghost{background:var(--surface);color:#475569;border-color:var(--line)}.button-ghost:hover{background:#f4f4f5}.table-wrap{overflow-x:auto;max-width:100%}table{width:100%;border-collapse:collapse;min-width:900px;font-size:.875rem}th,td{text-align:left;vertical-align:middle}th{padding:8px 8px 8px 0;border-bottom:1px solid var(--line);color:var(--muted);font-weight:500;white-space:nowrap}td{padding:5px 8px 5px 0;border-bottom:1px solid #f1f5f9}td input,td select{min-width:92px;min-height:32px}.action-col{width:118px;text-align:center}.icon-button{width:30px;height:30px;border:1px solid transparent;border-radius:8px;background:transparent;color:#94a3b8;font-size:.95rem;padding:0}.icon-button:hover{background:#f4f4f5;color:#475569}.icon-button.danger:hover{color:#ef4444}.help-text{margin:8px 2px 0;color:var(--muted);font-size:.75rem}.summary-grid{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:10px;margin-bottom:14px}.summary-item{padding:12px 14px;border:1px solid var(--line);border-radius:8px;background:var(--surface-soft)}.summary-label{display:block;color:var(--muted);font-size:.7rem;font-weight:600}.summary-value{display:block;margin-top:2px;font-size:1rem;font-weight:700}.alerts{display:grid;gap:6px;margin-bottom:14px}.alert{padding:10px 12px;border-radius:8px;font-size:.8rem}.alert-warning{background:var(--warning-soft);color:var(--warning)}
.alert-danger{background:var(--danger-soft);color:var(--danger)}.alert-success{background:var(--success-soft);color:var(--success)}.status{display:inline-block;padding:2px 8px;border-radius:999px;font-size:.75rem;font-weight:500;white-space:nowrap}.status-ok{background:var(--primary);color:#fff}.status-warning{background:#fef3c7;color:#b45309}.paste-area{width:100%;min-height:72px;margin:8px 0;border:1px solid var(--line);border-radius:8px;padding:8px 12px;font-family:inherit;font-size:.8rem;resize:vertical}.paste-panel{margin:0 0 14px;padding:14px;border:1px solid var(--line);border-radius:10px;background:var(--surface-soft)}.paste-panel-heading{display:flex;align-items:flex-start;justify-content:space-between;gap:12px}.paste-panel-heading strong{font-size:.875rem}.paste-panel-heading p{margin-top:3px;color:var(--muted);font-size:.75rem}.paste-panel .paste-area{margin:10px 0}.paste-status{font-size:.75rem;color:var(--muted)}.paste-status-success{color:var(--success)}.paste-status-warning{color:var(--warning)}
.hidden{display:none!important}.results-chart{overflow-x:auto;margin:16px 0}.results-chart svg{display:block}.notes-card{box-shadow:none}.notes-card ul{margin:12px 0 0;padding-left:1.25rem;color:var(--muted);font-size:.8rem}.notes-card li+li{margin-top:5px}.site-footer{padding:24px 0;color:#94a3b8;text-align:center;font-size:.75rem}

.plate-settings-grid{display:grid;grid-template-columns:repeat(5,minmax(120px,1fr));gap:12px;align-items:end}.inline-control{display:flex;gap:8px}.inline-control select{min-width:0}.template-control{flex-wrap:wrap}.template-control select{flex:1 1 220px}.template-control .button{flex:0 0 auto}.field-wide{min-width:240px;grid-column:1/-1}.subsection-heading{display:flex;align-items:end;justify-content:space-between;gap:16px;margin:22px 0 8px}.subsection-heading p{margin-top:3px;color:var(--muted);font-size:.75rem}.block-table-wrap{border-top:1px solid #f1f5f9}.block-table{min-width:860px}.block-table td:first-child,.block-table th:first-child{text-align:center;width:76px}.block-table .break-toggle{width:18px;min-width:18px;min-height:18px;accent-color:var(--primary)}.block-table .repeat-input{min-width:68px;width:68px}.block-actions{display:flex;justify-content:center;gap:2px}.plate-alert{margin-top:14px}.plate-scroll{overflow-x:auto;padding:4px 0 8px}.plate-grid{--plate-cols:12;--plate-rows:8;--well-width:68px;--well-height:56px;display:grid;grid-template-columns:28px repeat(var(--plate-cols),var(--well-width));grid-template-rows:24px repeat(var(--plate-rows),var(--well-height));gap:5px;width:max-content;min-width:100%;align-items:stretch}.well-group{display:flex;gap:inherit;margin:-2px;padding:.5px;border:1.5px solid rgba(100,116,139,.45);border-radius:10px;background:rgba(100,116,139,.05)}.well-group.vertical{flex-direction:column}.plate-grid.plate-384{--well-width:50px;--well-height:44px;gap:4px}.plate-corner,.plate-col-label,.plate-row-label{display:flex;align-items:center;justify-content:center;color:var(--muted);font-size:.7rem;font-weight:600}.plate-well{position:relative;border:1px solid #dbe3e8;border-radius:9px;background:#fbfcfd;min-width:var(--well-width);min-height:var(--well-height);padding:5px 6px;text-align:left;color:var(--muted);overflow:hidden}.plate-grid.plate-384 .plate-well{border-radius:7px;padding:4px}.plate-grid.plate-384 .well-sample{margin-top:3px;font-size:.58rem}.plate-grid.plate-384 .well-gene{font-size:.55rem}.plate-grid.plate-384 .well-role{font-size:.47rem;right:3px;top:3px}.plate-grid.plate-384 .well-id{font-size:.52rem}.plate-well.empty{cursor:pointer}.plate-well.empty:hover{border-color:#99f6e4;background:var(--primary-soft)}.well-id{display:block;font-size:.58rem;color:#94a3b8;line-height:1}.well-sample{display:block;margin-top:5px;font-size:.68rem;font-weight:650;color:#334155;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}.well-gene{display:block;font-size:.62rem;color:#64748b;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}.plate-well.group-0{background:#f8fafc;border-color:#cbd5e1}.plate-well.group-1{background:#f0fdfa;border-color:#5eead4}.plate-well.group-2{background:#ecfdf5;border-color:#86efac}.plate-well.group-3{background:#f5f3ff;border-color:#c4b5fd}.plate-well.group-4{background:#fff7ed;border-color:#fdba74}.plate-well.group-5{background:#fdf2f8;border-color:#f9a8d4}.plate-well.reference{border-style:dashed}.well-role{position:absolute;right:4px;top:4px;font-size:.52rem;padding:1px 4px;border-radius:99px;background:rgba(255,255,255,.75);color:#64748b}.plate-legend{display:flex;align-items:center;gap:12px;flex-wrap:wrap;margin-top:3px}.legend-item{display:flex;align-items:center;gap:5px;font-size:.7rem;color:var(--muted)}.legend-dot{width:12px;height:12px;border:1px solid #cbd5e1;border-radius:4px}.legend-dot.group-0{background:#f8fafc}.legend-dot.group-1{background:#f0fdfa;border-color:#5eead4}.legend-dot.group-2{background:#ecfdf5;border-color:#86efac}.legend-dot.group-3{background:#f5f3ff;border-color:#c4b5fd}.legend-dot.group-4{background:#fff7ed;border-color:#fdba74}.legend-dot.group-5{background:#fdf2f8;border-color:#f9a8d4}.legend-line{width:16px;border-top:1px dashed #64748b}.legend-frame{width:14px;height:12px;border:1.5px solid rgba(100,116,139,.45);border-radius:5px}.wells-input{min-width:118px!important}.ct-input{min-width:76px!important}.sample-row-warning td{background:#fffbeb}

@media(max-width:1100px){.plate-settings-grid{grid-template-columns:repeat(5,minmax(96px,1fr))}.field-wide{grid-column:1/-1}.plate-grid{min-width:auto}}
@media(max-width:639px){.site-header{padding:12px 0}.header-inner{gap:12px}.brand-bold,.brand-light{font-size:1.125rem}.header-divider{height:32px}.header-info h1{font-size:1rem}.subtitle{font-size:.75rem}}
@media(max-width:768px){.form-grid{grid-template-columns:1fr 1fr}.summary-grid{grid-template-columns:1fr 1fr}.card{padding:20px}.plate-settings-grid{grid-template-columns:1fr 1fr}.subsection-heading{align-items:flex-start;flex-direction:column}}
@media(max-width:480px){.container{padding:0 8px}.main-grid{gap:16px;margin-top:16px}.card{padding:14px}.section-heading{align-items:flex-start;flex-direction:column;gap:10px}.form-grid,.plate-settings-grid{grid-template-columns:1fr}.field-wide{grid-column:auto}.subtitle{white-space:normal}.button-row{width:100%}.button-row .button{flex:1 1 auto}.inline-control{align-items:stretch}.inline-control .button{flex:0 0 auto}}
.append-group{display:flex;align-items:center;gap:8px;flex-wrap:wrap;border-left:1px solid var(--line);padding-left:12px}.append-count-label{display:flex;align-items:center;gap:4px;color:var(--muted);font-size:.8rem;white-space:nowrap}.append-count{width:58px!important;min-width:58px!important;text-align:center;padding-left:6px;padding-right:6px}.paste-panel .button-row{align-items:center}.paste-panel .paste-status{flex:1 1 320px}.plate-card .plate-scroll{scrollbar-gutter:stable}
@media(max-width:720px){.template-control{flex-wrap:wrap}.template-control select{flex-basis:100%}.append-group{margin-left:auto;border-left:none;padding-left:0}}
.append-line-label{display:flex;align-items:center;gap:5px;color:var(--muted);font-size:.78rem;white-space:nowrap}.append-line-label input{width:16px!important;min-width:16px!important;min-height:16px!important;accent-color:var(--primary);padding:0}